| Category | Systolic (mmHg) | Diastolic (mmHg) | Action |
|---|---|---|---|
| Normal | <120 | <80 | Healthy lifestyle; reassess annually |
| Elevated | 120–129 | <80 | Lifestyle modification; reassess in 3–6 months |
| Stage 1 HTN | 130–139 | 80–89 | Lifestyle + medication if high CV risk or 10-yr ASCVD ≥10% |
| Stage 2 HTN | ≥140 | ≥90 | Lifestyle + two-drug combination therapy |
| Hypertensive Urgency | ≥180 | ≥120 | No end-organ damage; oral meds; gradual lowering over 24–48h |
| Hypertensive Emergency | ≥180 | ≥120 | End-organ damage present; IV antihypertensives; ICU admission |
| Condition | Target BP | Rationale |
|---|---|---|
| Uncomplicated hypertension | <130/80 mmHg | ACC/AHA 2017 guideline |
| Diabetes mellitus | <130/80 mmHg | Reduces diabetic nephropathy and retinopathy progression |
| Chronic kidney disease (CKD) | <130/80 mmHg | Slows CKD progression; ACE inhibitor or ARB preferred (renoprotective) |
| Heart failure with reduced EF | <130/80 mmHg | ACE inhibitor/ARB + beta-blocker are disease-modifying |
| Post-MI | <130/80 mmHg | Beta-blocker + ACE inhibitor improve mortality |
| Ischemic stroke (acute, first 24h) | Permissive: do NOT treat unless SBP >220 | Preserves penumbra perfusion |
| Hemorrhagic stroke (acute) | SBP <140 mmHg | Reduces hematoma expansion |
| Elderly (≥65) | <130 mmHg SBP (if tolerated) | Benefit shown in SPRINT trial; watch for orthostatic hypotension and falls |
| Pregnancy (chronic HTN) | 130–150/80–100 mmHg | Avoid ACE inhibitors and ARBs in pregnancy (teratogenic) |
| Class | Examples | Mechanism | Key Nursing Points |
|---|---|---|---|
| ACE Inhibitors | Lisinopril, enalapril, captopril, ramipril (-pril) | Block angiotensin-converting enzyme → no angiotensin II → vasodilation + reduced aldosterone | Dry cough (most common side effect — switch to ARB); monitor K+ and creatinine; AVOID in pregnancy; first-dose hypotension; angioedema (rare but dangerous) |
| ARBs (Angiotensin Receptor Blockers) | Losartan, valsartan, olmesartan, irbesartan (-sartan) | Block AT1 receptor → vasodilation; no cough (no bradykinin effect) | No cough (unlike ACEi); monitor K+ and creatinine; AVOID in pregnancy; similar renoprotection as ACEi; angioedema possible (less common) |
| Thiazide Diuretics | Hydrochlorothiazide (HCTZ), chlorthalidone, indapamide | Inhibit Na/Cl reabsorption in distal convoluted tubule → sodium/water excretion | Monitor Na+, K+ (hypokalemia), glucose (hyperglycemia), uric acid (gout); first-line for uncomplicated HTN; avoid in sulfa allergy; effective in Black patients |
| Calcium Channel Blockers (Dihydropyridines) | Amlodipine, nifedipine, felodipine (-dipine) | Block L-type calcium channels in vascular smooth muscle → vasodilation | Peripheral edema (most common); reflex tachycardia with nifedipine; grapefruit juice interaction; no negative cardiac effects at typical doses |
| Calcium Channel Blockers (Non-DHP) | Verapamil, diltiazem | Block calcium channels in heart AND vessels → reduced HR + vasodilation | Avoid with heart block, bradycardia, severe HF; constipation (verapamil); monitor HR and PR interval; drug interactions (digoxin, statins) |
| Beta-Blockers | Metoprolol, atenolol, carvedilol, labetalol (-olol) | Block beta-adrenergic receptors → reduced HR and CO; reduced renin | Do NOT stop abruptly (rebound hypertension/angina); avoid in asthma/COPD (selective beta-1 preferred); mask hypoglycemia symptoms; bradycardia, fatigue, cold extremities; carvedilol = alpha + beta (used in HF) |
| Aldosterone Antagonists | Spironolactone, eplerenone | Block aldosterone → K+-sparing diuresis | Hyperkalemia risk (avoid with ACEi/ARB in CKD); gynecomastia with spironolactone; useful in resistant HTN + HF |
| Alpha-1 Blockers | Prazosin, doxazosin, terazosin | Block alpha-1 receptors → vasodilation | Orthostatic hypotension (especially first-dose — "first-dose effect"); used in BPH + HTN; advise to take at bedtime |
| Central Alpha-2 Agonists | Clonidine, methyldopa | Stimulate alpha-2 receptors in brainstem → reduced sympathetic outflow | Rebound HTN if stopped abruptly (clonidine); sedation, dry mouth; methyldopa = drug of choice in pregnancy; clonidine patch available |
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