Part of the ICU Emergencies Hub — browse every related guide in one place.
| Parameter | Definition | Typical Range |
|---|---|---|
| Demand dose (PCA dose) | The amount of opioid delivered when the patient presses the button | Morphine: 1–2 mg; Hydromorphone: 0.2–0.4 mg; Fentanyl: 10–20 mcg |
| Lockout interval | Minimum time between doses — the pump will not deliver another dose if pressed during lockout | 6–10 minutes (most common); allows previous dose to reach peak effect before next is possible |
| Basal rate (continuous infusion) | Continuous background opioid infusion running regardless of button presses | Generally avoided in opioid-naive patients; used for opioid-tolerant patients or specific protocols |
| 1-hour limit / 4-hour limit | Maximum total opioid deliverable within that time window (both basal + demand) | Varies by drug and patient; provider-set safety ceiling |
| Attempts vs. deliveries | PCA pump records how many times the button was pressed (attempts) vs. how many doses were actually delivered | High attempts with low deliveries = patient in pain; lockout interval may need adjusting |
PCA patients require nursing assessment at least every 2 hours — more frequently in the first hour after initiation or after any parameter change. The Q2H PCA assessment covers:
Pain score: Using the patient's self-reported pain scale. Compare to previous assessment — is pain improving, stable, or worsening? If the patient is pressing the button frequently (high attempts) but still reporting uncontrolled pain, the PCA parameters may need adjustment — notify the provider.
Sedation level: The most important safety parameter, monitored using the Pasero Opioid-Induced Sedation Scale (POSS): S = Sleep, easy to arouse (acceptable); 1 = Awake and alert (acceptable); 2 = Slightly drowsy, easily aroused (acceptable); 3 = Frequently drowsy, arousable, drifts off during conversation (unacceptable — reduce or hold PCA, notify provider); 4 = Somnolent, minimal or no response to stimulation (unacceptable — stop PCA, call rapid response, prepare naloxone).
Respiratory rate and SpO2: Respiratory depression (RR <8–10) is the life-threatening complication of PCA opioid excess. SpO2 is less sensitive than respiratory rate for early opioid-induced respiratory depression because patients may maintain oxygen saturation while hypoventilating on supplemental oxygen. End-tidal CO2 monitoring (capnography) is the most sensitive continuous monitor for respiratory depression — ordered for high-risk PCA patients at many institutions.
Attempts vs. deliveries review: Document and review the PCA pump's log. Patterns: many attempts during nighttime when the patient was sleeping suggests a visitor was pressing the button (PCA by proxy). Consistently high attempts with high deliveries and still uncontrolled pain warrants a provider call for reassessment. Very few attempts with well-controlled pain = PCA working as intended.
| Drug | Typical PCA Dose | Lockout | Key Nursing Notes |
|---|---|---|---|
| Morphine | 1–2 mg per dose | 6–10 min | Histamine release can cause pruritus and hypotension; active metabolite (morphine-6-glucuronide) accumulates in renal failure — use with caution in AKI/CKD |
| Hydromorphone (Dilaudid) | 0.2–0.4 mg per dose | 6–10 min | 5–10x more potent than morphine; preferred in renal failure (fewer active metabolites than morphine); less pruritus than morphine |
| Fentanyl | 10–25 mcg per dose | 6–10 min | Fastest onset (1–2 min); shortest duration; preferred in hemodynamically unstable patients (least hypotension); accumulates with prolonged infusion (lipophilic) |
Continuous basal opioid infusions with PCA are generally avoided in opioid-naive patients — basal rates do not improve pain control but significantly increase the risk of respiratory depression and oversedation in patients without opioid tolerance. The self-regulation mechanism of PCA (sedated patient can't push button) does not apply to the basal rate, which runs continuously regardless of patient responsiveness.
Basal rates are appropriate in: opioid-tolerant patients (chronic opioid users, patients on significant home opioid doses requiring a basal replacement); patients with known opioid-responsive pain conditions where background analgesia is medically established; palliative care settings where comfort is the priority. Always requires explicit provider order with documentation of opioid tolerance.
Naloxone (Narcan) must be available at the bedside of every PCA patient — this is a Joint Commission requirement. Typical reversal protocol for respiratory depression (POSS 4): administer 0.4 mg naloxone IV push slowly (or 0.04 mg diluted in 10 mL NS for titrated reversal in post-operative patients — reverse respiratory depression without completely reversing analgesia and precipitating severe pain). Notify provider immediately. Continuous monitoring. The duration of most opioids exceeds the duration of naloxone (30–60 minutes for IV naloxone) — re-sedation can occur; the patient may require repeated doses or a continuous naloxone infusion.
Related guides: Pain assessment | Medication routes | Post-op complications
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